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IMMUNOGLOBULIN FAB FRAGMENTS
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DeCS
Descriptor
English
:
Immunoglobulin Fab Fragments
Descriptor
Spanish
:
Fragmentos Fab de Inmunoglobulinas
Descriptor
Portuguese
:
Fragmentos Fab das Imunoglobulinas
Synonyms
English
:
Fab Fragments
Immunoglobulins, Fab Fragment
Tree Number:
D12.776.124.486.485.680.650
D12.776.124.486.485.797.570
D12.776.124.790.651.680.650
D12.776.124.790.651.797.570
D12.776.377.715.548.680.650
D12.776.377.715.548.797.570
Definition
English
:
Univalent antigen-binding fragments composed of one entire IMMUNOGLOBULIN
LIGHT
CHAIN and the amino terminal end of one of the
IMMUNOGLOBULIN HEAVY CHAINS
from the hinge region, linked to each other by disulfide bonds. Fab contains the IMMUNOGLOBULIN VARIABLE REGIONS, which are part of the antigen-binding site, and the first
IMMUNOGLOBULIN CONSTANT REGIONS
. This fragment can be obtained by
digestion
of
immunoglobulins
with the proteolytic enzyme
PAPAIN.
Indexing Annotation
English
:
DF: IG FAB
Pharmacological Action:
Immunologic Factors
History Note
English
:
2006 (1973)
Allowable Qualifiers
English
:
administration & dosage
adverse effects
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
contraindications
drug effects
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
poisoning
radiation effects
toxicity
therapeutic use
ultrastructure
urine
Record Number:
22214
Unique Identifier:
D007140
Occurrence in VHL
:
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